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Clinical usefulness of bone turnover marker concentrations in osteoporosis
Morris, H. A. Eastell, R. Jorgesen, N. R. Cavalier, E. Vasikaran, S. Chubb, S. A. P. Kanis, J. A. Cooper, C. Makris, K.
Morris, H. A.
Eastell, R.
Jorgesen, N. R.
Cavalier, E.
Vasikaran, S.
Chubb, S. A. P.
Kanis, J. A.
Cooper, C.
Makris, K.
Abstract
Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the limitations identified earlier remain, principally in regard to the relationship between BTM and incident fractures. Important data are now available on reference interval values for CTX and PINP across a range of geographic regions and for individual clinical assays. An apparent lack of comparability between current clinical assays for CTX has become evident indicating the possible limitations of combining such data for meta-analyses. Harmonization of units for reporting serum/plasma CTX (ng/L) and PINP (μg/L) is recommended. The development of international collaborations continues with an important initiative to combine BTM results from clinical trials in osteoporosis in a meta-analysis and an assay harmonization program are likely to be beneficial. It is possible that knowledge derived from clinical studies can further enhance fracture risk estimation tools with inclusion of BTM together with other independent risk factors. Further data of the relationships between the clinical assays for CTX and PINP as well as physiological and pre-analytical factors contributing to variability in BTM concentrations are required.
Keywords
bone turnover markers, osteoporosis, fracture risk, reference intervals, monitoring efficacy for treatment of osteoporosis, CTX, PINP
Date
2017
Type
Journal article
Journal
Clinica Chimica Acta
Book
Volume
467
Issue
Page Range
34-41
Article Number
ACU Department
School of Nursing, Midwifery and Paramedicine
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled