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Extensive type ii muscle fiber atrophy in elderly female hip fracture patients
Kramer, Irene F. Snijders, Tim Smeets, Joey S.J. Leenders, Marika van Kranenburg, Janneau den Hoed, Marcel Verdijk, Lex B. Poeze, Martijn Van Loon, Luc
Kramer, Irene F.
Snijders, Tim
Smeets, Joey S.J.
Leenders, Marika
van Kranenburg, Janneau
den Hoed, Marcel
Verdijk, Lex B.
Poeze, Martijn
Van Loon, Luc
Abstract
Background Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip fracture patients. Method Percutaneous needle biopsies were collected from the vastus lateralis muscle in 15 healthy young women (20 ± 0.4 years), 15 healthy elderly women (79 ± 1.7 years), and 15 elderly women with a fall-related hip fracture (82 ± 1.5 years). Immunohistochemical analyses were performed to assess Type I and Type II muscle fiber size, and myonuclear and satellite cell content. Results Type II muscle fiber size was significantly different between all groups (p < .05), with smaller Type II musclefibers in the hip fracture patients (2,609 ± 185 μm 2) compared with healthy elderly group (3,723 ± 322 μm 2) and the largest Type II muscle fibers in the healthy young group (4,755 ± 335 μm 2). Furthermore, Type I muscle fiber size was significantly lower in the hip fracture patients (4,684 ± 211 μm 2) compared with the healthy elderly group (5,842 ± 316 μm 2, p =.02). The number of myonuclei per Type II muscle fiber was significantly lower in the healthy elderly and hip fracture group compared with the healthy young group (p =.011 and p =.002, respectively). Muscle fiber satellite cell content did not differ between groups. Conclusion Elderly female hip fracture patients show extensive Type II muscle fiber atrophy when compared with healthy young or age-matched healthy elderly controls. Type II muscle fiber atrophy is an important hallmark of sarcopenia and may predispose to falls and (hip) fractures inthe older population.
Keywords
falls, hip fracture, muscle, sarcopenia
Date
2017
Type
Journal article
Journal
The Journals of Gerontology: Series A
Book
Volume
72
Issue
10
Page Range
1369-1375
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled