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Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging
Crane, Justin D. MacNeil, Lauren G. Lally, James S. V. Ford, Rebecca J. Bujak, Adam L. Brar, Ikdip K. Kemp, Bruce Ernest Raha, Sandeep Steinberg, Gregory Robert Tarnopolsky, Mark A.
Crane, Justin D.
MacNeil, Lauren G.
Lally, James S. V.
Ford, Rebecca J.
Bujak, Adam L.
Brar, Ikdip K.
Kemp, Bruce Ernest
Raha, Sandeep
Steinberg, Gregory Robert
Tarnopolsky, Mark A.
Abstract
Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefits, there is no evidence that it affects skin tissue or that endocrine muscle-to-skin signaling occurs. We demonstrate that endurance exercise attenuates age-associated changes to skin in humans and mice and identify exercise-induced IL-15 as a novel regulator of mitochondrial function in aging skin. We show that exercise controls IL-15 expression in part through skeletal muscle AMP-activated protein kinase ( AMPK) , a central regulator of metabolism, and that the elimination of muscle AMPK causes a deterioration of skin structure. Finally, we establish that daily IL-15 therapy mimics some of the anti-aging effects of exercise on muscle and skin in mice. Thus, we elucidate a mechanism by which exercise confers health benefits to skin and suggest that low-dose IL-15 therapy may prove to be a beneficial strategy to attenuate skin aging.
Keywords
aging, exercise, muscle, metabolism, mitochondria, skin
Date
2015
Type
Journal article
Journal
Aging Cell
Book
Volume
14
Issue
4
Page Range
625-634
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open
Notes
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.