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Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
Bhattoa, Harjit P. Cavalier, Etienne Eastell, Richard Heijboer, Annemieke C. Jørgensen, Niklas R. Makris, Konstantinos Ulmer, Candice Z. Kanis, John A. Cooper, Cyrus Silverman, Stuart L.
Bhattoa, Harjit P.
Cavalier, Etienne
Eastell, Richard
Heijboer, Annemieke C.
Jørgensen, Niklas R.
Makris, Konstantinos
Ulmer, Candice Z.
Kanis, John A.
Cooper, Cyrus
Silverman, Stuart L.
Abstract
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
Keywords
procollagen type I N-propeptide, PINP, C-terminal telopeptide of type I collagen, β-CTX, bone turnover markers, bone formation, bone resorption, standardization, harmonization
Date
2021
Type
Journal article
Journal
Clinica Chimica Acta
Book
Volume
515
Issue
Page Range
16-20
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Open
Controlled
Controlled